Clinical relevance of T follicular helper cells in systemic lupus erythematosus.

Published in: Expert review of clinical immunology (2021)

Tfh cells are involved in the pathogenesis of SLE based on their plasticity and diversity. Tfh cell differentiation and function are variably regulated by cytokines (IL-12, interferons, IL-2, etc), co-stimulatory molecules (ICOS, CD40L, OX40, etc), and intracellular signals (JAK-STAT, etc). Elucidation of the mechanisms underlying Tfh cell differentiation and function may lead to the development of new therapies for SLE.

Keyphrases

induced apoptosis
systemic lupus erythematosus
cell cycle arrest
disease activity
regulatory t cells
cell death
signaling pathway
dendritic cells
pi k akt