Genetic Heterogeneity Between Paired Primary and Brain Metastases in Lung Adenocarcinoma.
Li LiZhulin LiuRui HanLin LiMengyao WangDepei HuangYong HePublished in: Clinical Medicine Insights. Oncology (2020)
The consistency of gene mutation between primary lung adenocarcinoma and corresponding BM is relatively high, while the individual differences were significant. FAM129C and ADAMTSs mutations and high amplification of NKX2-1 may be related to BM of lung cancer. The loss of copy number of SAMD2/4 may be a potential therapeutic target for BM from lung adenocarcinoma.