Induction of high affinity monoclonal antibodies against SARS-CoV-2 variant infection using a DNA prime-protein boost strategy.

Chen-Yi ChiangMei-Yu ChenChia-Wei HsuChia-Yeh LiuYu-Wen TsaiHung-Chun LiaoJia-Ying YanZih-Shiuan ChuangHsin-I WangChien-Hsiung PanChia-Yi YuGuann-Yi YuChing-Len LiaoShih-Jen LiuHsin-Wei Chen

Published in: Journal of biomedical science (2022)

Our approach generates high-potency monoclonal antibodies against a broad spectrum of VOCs. Multiple monoclonal antibody combinations may be the best strategy to treat future SARS-CoV-2 variant outbreaks.

Keyphrases

sars cov
monoclonal antibody
respiratory syndrome coronavirus
circulating tumor
single molecule
binding protein