Lipid Based Formulations in Hard Gelatin and HPMC Capsules: a Physical Compatibility Study.
Niklas J KoehlSanket ShahIngrid Djouka TenekamTatsiana KhamiakovaNicolas SauwenSien VingerhoetsHans CoppenolleRené HolmPublished in: Pharmaceutical research (2021)
The capsule compatibility was driven by the components incorporated into the formulations, where more was compatible with gelatin than HPMC capsules. Prediction of the mass change from individual excipient contributions can provide a good first estimate if a vehicle is compatible with a capsule, however, this needs to be proved experimentally.