GRPR/PI3Kγ: Partners in Central Transmission of Itch.
Paula J S PereiraGustavo D B MachadoGiuliano M DanesiFrancesca F CaneveseVemuri B ReddyTalita C B PereiraMaurício R BogoYung-Chih ChengCedric LaedermannSébastien TalbotEthan A LernerMaria M CamposPublished in: The Journal of neuroscience : the official journal of the Society for Neuroscience (2016)
Itch is the most common symptom of the skin and is related to noncutaneous diseases. It severely impairs patients' quality of life when it becomes chronic and there is no specific or effective available therapy, mainly because itch pathophysiology is not completely elucidated. Our findings indicate that the enzyme PI3Kγ is a key central mediator of itch transmission. Therefore, we suggest PI3Kγ as an attractive target for the development of new anti-pruritic drugs. With this study, we take a step forward in our understanding of the mechanisms underlying the central transmission of itch sensation.