Concise Review: Developing Best-Practice Models for the Therapeutic Use of Extracellular Vesicles.
Agnes T ReinerKenneth W WitwerBas W M van BalkomJoel de BeerChaya BrodieRandolph L CortelingSusanne GabrielssonMario GimonaAhmed G IbrahimDominique de KleijnCharles P LaiJan LötvallHernando A Del PortilloIlona G ReischlMilad RiazifarCarlos SalomonHidetoshi TaharaWei Seong TohMarca H M WaubenVicky K YangYijun YangRonne Wee Yeh YeoHang YinBernd GiebelEva RohdeSai Kiang LimPublished in: Stem cells translational medicine (2017)
Growing interest in extracellular vesicles (EVs, including exosomes and microvesicles) as therapeutic entities, particularly in stem cell-related approaches, has underlined the need for standardization and coordination of development efforts. Members of the International Society for Extracellular Vesicles and the Society for Clinical Research and Translation of Extracellular Vesicles Singapore convened a Workshop on this topic to discuss the opportunities and challenges associated with development of EV-based therapeutics at the preclinical and clinical levels. This review outlines topic-specific action items that, if addressed, will enhance the development of best-practice models for EV therapies. Stem Cells Translational Medicine 2017;6:1730-1739.