Alterations in genetic pathways following radiotherapy for head and neck cancer.

Arash O NaghaviYoungchul KimGeorge Q YangKamran A AhmedJimmy J Caudell

Published in: Head & neck (2019)

Patients with recurrences salvaged surgically post-RT had significant alterations in gene-expression and in Wnt/B-catenin and MYC-target pathways. These pathways may represent potential targets to prevent development of resistance to RT.

Keyphrases

gene expression
cell proliferation
early stage
stem cells
dna methylation
radiation therapy
epithelial mesenchymal transition
transcription factor
squamous cell carcinoma
locally advanced