Association of Germline BRCA Pathogenic Variants With Diminished Ovarian Reserve: A Meta-Analysis of Individual Patient-Level Data.
Volkan TuranMatteo LambertiniDong-Yun LeeErica WangFlorian ClatotBeth Y KarlanIsabelle DemeestereHeejung BangKutluk H OktayPublished in: Journal of clinical oncology : official journal of the American Society of Clinical Oncology (2021)
Young women with gBRCA pathogenic variants, particularly those affected and with gBRCA1, have lower serum AMH levels compared with controls. They may need to be preferentially counseled about the possibility of shortened reproductive lifespan because of diminished ovarian reserve.