Altered levels of phospholipases C, diacylglycerols, endocannabinoids, and N-acylethanolamines in patients with hereditary angioedema due to FXII mutation.
Anne Lise FerraraFrancesco PalestraFabiana PiscitelliAngelica PetraroliChiara SuffrittiDavide FirinuAlberto López-LeraTeresa CaballeroKonrad BorkGiuseppe SpadaroGiancarlo MaroneVincenzo Di MarzoMaria BovaStefania LoffredoPublished in: Allergy (2024)
BK overproduction and BKR2 activation are linked to alteration of PLCs and their metabolites in patients with FXII-HAE. Our results may pave way to investigations on the functions of these mediators in the pathophysiology of FXII-HAE, and provide new potential biomarkers and therapeutic targets.
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