Intratumoral Tumor Infiltrating Lymphocytes (TILs) are Associated With Cell Proliferation and Better Survival But Not Always With Chemotherapy Response in Breast Cancer.
Rongrong WuMasanori OshiMariko AsaokaLi YanMatthew G K BeneschThaer KhouryMasayuki NagahashiYasuo MiyoshiItaru EndoTakashi IshikawaKazuaki TakabePublished in: Annals of surgery (2023)
Intratumoral TILs estimated by transcriptome computation were associated with increased immune response and cell proliferation in ER-positive/HER2-negative and better survival in HER2-positive and TNBC subtypes, but not always with pCR after neoadjuvant chemotherapy.
Keyphrases
- neoadjuvant chemotherapy
- cell proliferation
- locally advanced
- immune response
- lymph node
- cell cycle
- sentinel lymph node
- rectal cancer
- free survival
- squamous cell carcinoma
- gene expression
- radiation therapy
- rna seq
- peripheral blood
- pi k akt
- genome wide
- toll like receptor
- early stage
- breast cancer cells
- endoplasmic reticulum
- real time pcr