A precision RNA degradation machinery shapes stem cell development.

Published in: The Journal of cell biology (2019)

In this issue, Belair et al. (2019. J. Cell Biol. https://doi.org/10.1083/jcb.201811148) show that, together with a complex network of transcription factors and chromatin modifiers, the RNA exosome regulates embryonic stem cell (ESC) differentiation and pluripotency.

Keyphrases

stem cells
transcription factor
cell therapy
single cell
nucleic acid
genome wide
dna binding
embryonic stem cells
dna methylation
oxidative stress
cell fate
bone marrow