Genetic Determinants of Drug Resistance in Mycobacterium tuberculosis and Their Diagnostic Value.

Maha Reda FarhatRazvan SultanaOleg IartchoukSam BozemanJames GalaganPeter SiskChristian StolteHanna Nebenzahl-GuimaraesKaren JacobsonAlexander SloutskyDevinder KaurJames PoseyBarry N KreiswirthNatalia KurepinaLeen RigoutsElizabeth M StreicherTommie C VictorRobin M WarrenDick van SoolingenMegan Murray

Published in: American journal of respiratory and critical care medicine (2017)

These data suggest that a comprehensive M. tuberculosis drug resistance diagnostic will need to allow for a high dimension of mutation detection. They also support the hypothesis that currently unknown genetic determinants, potentially discoverable by whole-genome sequencing, encode resistance to second-line tuberculosis drugs.

Keyphrases

mycobacterium tuberculosis
pulmonary tuberculosis
genome wide
copy number
hiv aids
electronic health record
big data
loop mediated isothermal amplification
label free
adverse drug
real time pcr
deep learning
hepatitis c virus
data analysis
quantum dots
antiretroviral therapy
drug induced
sensitive detection