Hypothalamic paraventricular nucleus hydrogen sulfide exerts antihypertensive effects in spontaneously hypertensive rats via the Nrf2 pathway.

Wen-Jie XiaKai-Li LiuXiao-Min WangYu YangTingting MengJin-An QiaoNianping ZhangYao-Jun SunYu-Ming KangXiao-Jing Yu

Published in: American journal of hypertension (2023)

The findings imply that endogenous H2S in SHR PVN is reduced, and PVN endogenous H2S can alleviate hypertension via Nrf2-mediated antioxidant and anti-inflammatory effects.

Keyphrases

oxidative stress
blood pressure
hypertensive patients