Caloric restriction prevents inflammation and insulin dysfunction in middle-aged ovariectomized mice.

Leticia Roberta Leme SapatiniBruno CalsaLais Jorge MarimJúlia Venturini HelaehilGabriela Bortolança ChiarottoMaria Esméria Corezola do Amaral

Published in: Molecular biology reports (2023)

In conclusion, CR improved the condition of ovariectomized mice by reducing adiposity and increasing insulin sensitivity and glucose tolerance through a mechanism that may involve AMPK.

Keyphrases

middle aged
high fat diet induced
oxidative stress
insulin resistance
type diabetes
bone loss
skeletal muscle
glycemic control
mouse model
body mass index
physical activity
weight gain
protein kinase
wild type
weight loss