Altered plasma protein profiles in genetic FTD - a GENFI study.
Abbe UllgrenLinn ÖijerstedtJennie OlofssonSofia BergströmJulia RemnestålJohn C van SwietenLize C JiskootHarro SeelaarBarbara BorroniRaquel Sanchez-ValleFermin MorenoRobert LaforceMatthis SynofzikDaniela GalimbertiJames B RoweMario MasellisMaria Carmela TartagliaElizabeth FingerRik VandenbergheAlexandre de MendonçaPietro TiraboschIsabel SantanaSimon DucharmeChris R ButlerAlexander GerhardMarkus OttoArabella BouziguesLucy RussellImogen J SwiftAitana Sogorb-EsteveCarolin HellerJonathan D RohrerAnna MånbergPeter NilssonCaroline Graffnull nullPublished in: Molecular neurodegeneration (2023)
We identified plasma proteins with altered levels in symptomatic mutation carriers compared to non-carrier controls as well as to presymptomatic mutation carriers. Further investigations are needed to elucidate their potential as fluid biomarkers of the disease process.