Vaccination with nanoparticles combined with micro-adjuvants protects against cancer.
Mona O MohsenMatthew D HeathGustavo Cabral-MirandaCyrill LippAndris ZeltinsMarcos SandeJens V SteinCarsten RietherElisa RoestiLisha ZhaPaul EngeroffAadil El-TurabiThomas M KundigMonique VogelMurray A SkinnerDaniel E SpeiserAlexander KnuthMatthias F KramerMartin F BachmannPublished in: Journal for immunotherapy of cancer (2019)
The combination of nano- and micro-particles may optimally harness the physiological properties of the lymphatic system. Since the nanoparticles are well defined virus-like particles and the micron-sized adjuvant MCT has been used for decades in allergen-specific desensitization, this approach may readily be translated to the clinic.