Hypericin-photodynamic therapy inhibits the growth of adult T-cell leukemia cells through induction of apoptosis and suppression of viral transcription.

Lingling XuXueqing ZhangWenzhao ChengYong WangKaining YiZhilong WangYiling ZhangLinxiang ShaoTiejun Zhao

Published in: Retrovirology (2019)

Our results revealed that hypericin-PDT is highly effective against ATL cells by induction of apoptosis and suppression of viral transcription. These studies highlight the promising use of hypericin-PDT as a targeted therapy for ATL.

Keyphrases

cell cycle arrest
photodynamic therapy
induced apoptosis
cell death
endoplasmic reticulum stress
pi k akt
oxidative stress
sars cov
transcription factor
acute myeloid leukemia
fluorescence imaging
bone marrow
single cell