Hypertonic Dextrose Stimulates Chondrogenic Cells to Deposit Collagen and Proliferate.

Elisha JohnstonYi KouJason JungeLin ChenAndrew KochanMichael JohnstonDavid Rabago

Published in: Cartilage (2021)

A 250 mM HD solution appears to be associated with increased metabolic activity of chondrocytes, increased collagen deposition, and increased chondrocyte proliferation. These results support clinical prolotherapy research suggesting that intra-articular HD joint injections reduce knee pain. Further study of HD and cellular processes is warranted.

Keyphrases

induced apoptosis
chronic pain
total knee arthroplasty
signaling pathway
pain management
cell cycle arrest
wound healing
neuropathic pain
tissue engineering
spinal cord injury
spinal cord
platelet rich plasma
postoperative pain