A Validated Assay to Quantify Osimertinib and Its Metabolites, AZ5104 and AZ7550, from Microsampled Dried Blood Spots and Plasma.

Bharat VenkateshAlex YuileMatthew J McKaySathya NarayananHelen WheelerMalinda ItchinsNick PavlakisStephen J ClarkeMark P Molloy

Published in: Therapeutic drug monitoring (2023)

The measurement of osimertinib, AZ5104, and AZ7550 from hemaPEN microsampled DBS is a convenient and reliable approach for therapeutic drug monitoring that produces measurements consistent with plasma drug levels.

Keyphrases

small cell lung cancer
advanced non small cell lung cancer
epidermal growth factor receptor
ms ms
high throughput
deep brain stimulation
emergency department
tyrosine kinase
adverse drug
drug induced