GPX3-Mediated Oxidative Stress Affects Pyrimidine Metabolism Levels in Stomach Adenocarcinoma via the AMPK/mTOR Pathway.

Yaowen Zhang Yixin Yang Shanshan Kuang Yang Zhang Hancheng Qin Jisheng Xie

Published in: International journal of clinical practice (2024)

GPX3 which regulates the level of pyrimidine metabolism through the AMPK/mTOR pathway was found to be closely associated with STAD. Our findings demonstrate GPX3 is a reliable biomarker for the prognosis of amino acid metabolism and a probable target for STAD therapy.

Keyphrases

oxidative stress
amino acid
skeletal muscle
cell proliferation
squamous cell carcinoma
dna damage
protein kinase
radiation therapy
signaling pathway
mesenchymal stem cells
heat shock
smoking cessation
heat stress
cell therapy