Insights into the regulation of glomerular filtration rate by the Keap1-Nrf2 pathway.

Kengo KidokoroHiroyuki KadoyaDavid Z I CherneyMegumi KondoYoshihisa WadaReina UmenoSeiji KishiHajime NagasuKojiro NagaiTakafumi SuzukiTamaki SasakiMasayuki YamamotoYashpal S KanwarNaoki Kashihara

Published in: Kidney360 (2023)

In conclusion, the Keap1-Nrf2 pathway regulates GFR through changes in ultrafiltration by modulating redox-sensitive intracellular calcium signaling and cellular contractility, mediated through TRPC activity, in glomerular cells, in particular the podocytes.

Keyphrases

oxidative stress
induced apoptosis
diabetic nephropathy
signaling pathway
cell cycle arrest
high glucose
protein protein
endoplasmic reticulum stress
cell death
cell proliferation