Intravitreal injection of the synthetic peptide LyeTx I b, derived from a spider toxin, into the rabbit eye is safe and prevents neovascularization in a chorio-allantoic membrane model.
Flavia Rodrigues da SilvaMayara Rodrigues Brandão de PaivaLays Fernanda Nunes DouradoRummenigge Oliveira SilvaCarolina Nunes da SilvaBruna Lopes da CostaCibele Rodrigues ToledoMaria Elena de LimaArmando da Silva-CunhaPublished in: The journal of venomous animals and toxins including tropical diseases (2018)
Intravitreal injection of LyeTx I b is safe for use in the rabbit eye and prevents neovascularization in the CAM model, at Bevacizumab levels. These findings support intravitreal LyeTx I b as a good candidate to develop future alternative treatment for the retina in neovascularization diseases.