Predictive Polygenic Score for Outcome after First-Line Oxaliplatin-Based Chemotherapy in Colorectal Cancer Patients Using Supervised Principal Component Analysis.

Hanla A Park Dominic Edelmann Frederico Canzian Tabitha A Harrison Xinwei Hua Qian Shi Allison Silverman Martin Schneider Richard M Goldberg Steven R Alberts Michael Hoffmeister Hermann Brenner Andrew T Chan Ulrike Peters Polly A Newcomb Jenny Chang-Claude

Published in: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology (2022)

These results highlight the potential but also challenges in generating evidence for a predictive polygenic score for oxaliplatin efficacy.

Keyphrases

end stage renal disease
ejection fraction
chronic kidney disease
machine learning
prognostic factors
squamous cell carcinoma
radiation therapy
risk assessment
rectal cancer