Nucleocytoplasmic transport rates are regulated by cellular processes that modulate GTP availability.
Kelsey L ScottCharles T HalfmannAllison D HoefakkerPurboja PurkayasthaTing Ching WangTanmay P LeleKyle J RouxPublished in: bioRxiv : the preprint server for biology (2023)
Changes in the availability of cellular GTP resulting from physiologically relevant processes, including cell migration and cell spreading, alter the rates of Ran-dependent nuclear import and export. Altered rates of nucleocytoplasmic transport regulate RNA localization and protein synthesis.