ASK1 Enhances Angiotensin II-Induced Liver Fibrosis In Vitro by Mediating Endoplasmic Reticulum Stress-Dependent Exosomes.

Pei-Pei FangChen-Wei PanWei LinJie LiShan-Shan HuangGuang-Yao ZhouWen-Jun DuQiang Li

Published in: Mediators of inflammation (2020)

In summary, we found that ASK1 mediates Ang II-activated ERS in HSCs and the subsequent activation of HSCs, suggesting a promising strategy for treating liver fibrosis.

Keyphrases

liver fibrosis
angiotensin ii
endoplasmic reticulum stress
induced apoptosis
angiotensin converting enzyme
vascular smooth muscle cells
mesenchymal stem cells
diabetic rats
stem cells
drug induced
signaling pathway
oxidative stress