Disentangling multiple sclerosis phenotypes through Mendelian disorders: A network approach.

Gianmarco BellucciMaria Chiara BuscarinuRoberta RenièVirginia RinaldiRachele BigiRosella MechelliSilvia RomanoMarco Salvetti Giovanni Ristori

Published in: Multiple sclerosis (Houndmills, Basingstoke, England) (2024)

The genetic architecture of MS contains the seeds of pathobiological multiplicities shared with immune, neurologic, metabolic and visual monogenic disorders. This result may inform future classifications of MS endophenotypes and support the development of new therapies in both MS and rare diseases.

Keyphrases

multiple sclerosis
mass spectrometry
ms ms
white matter
genome wide
gene expression
dna methylation