A therapeutic target for CKD: activin A facilitates TGFβ1 profibrotic signaling.
Asfia SoomroMohammad KhajeheiRenzhong LiKian O'NeilDan ZhangBo GaoMelissa MacDonaldMasao KakokiJoan C KrepinskyPublished in: Cellular & molecular biology letters (2023)
Activin A facilitates TGFβ1 profibrotic effects through regulation of both canonical (Smad3) and non-canonical (MRTF-A) signaling, suggesting it may be a novel therapeutic target for preventing fibrosis in CKD.