Molecular mechanisms by which splice modulator GEX1A inhibits leukaemia development and progression.
Mark SellinRyan MackMatthew C RhodesLei ZhangStephanie BergKanak JoshiShanhui LiuWei WeiPeter Breslin S JPeter LarsenRichard E TaylorJiwang ZhangPublished in: British journal of cancer (2022)
Our study suggests that GEX1A is a potent anti-leukaemic agent in combination with BCL-xL inhibitors, which targets leukaemic blasts and leukaemia stem cells through distinct mechanisms.