Usefulness of baseline statin therapy in non-obstructive coronary artery disease by coronary computed tomographic angiography: From the CONFIRM (COronary CT Angiography EvaluatioN For Clinical Outcomes: An InteRnational Multicenter) study.
Yun-Kyeong ChoChang Wook NamBon-Kwon KooJoshua Schulman-MarcusBríain Ó HartaighHeidi GransarYao LuStephan AchenbachMouaz Al-MallahDaniele AndreiniJeroen J BaxMatthew J BudoffFilippo CademartiriTracy Q CallisterHyuk-Jae ChangKavitha ChinnaiyanBenjamin J W ChowRicardo C CuryAugustin DelagoGudrun FeuchtnerMartin HadamitzkyJörg HausleiterPhilipp A KaufmannYong-Jin KimJonathon LeipsicErica MaffeiHugo MarquesGianluca PontoneGilbert L RaffRonen RubinshteinLeslee J ShawTodd C VillinesDaniel S BermanErica C JonesJessica M PeñaFay Y LinJames K MinPublished in: PloS one (2018)
In individuals with non-obstructive coronary artery disease, increased risk of adverse events occurs with increasing CAC or SIS who are not on baseline statin therapy. Statin therapy is associated with a mitigation of risk of cardiac events in the presence of increasing atherosclerosis, with no particular threshold of disease burden.