The Intracellular Delivery Of Anti-HPV16 E7 scFvs Through Engineered Extracellular Vesicles Inhibits The Proliferation Of HPV-Infected Cells.

Flavia FerrantelliClaudia ArenaccioFrancesco ManfrediEleonora OlivettaChiara ChiozziniPatrizia LeoneZulema PercarioAlessandro AscioneMichela FlegoPaola Di BonitoLuisa AccardiMaurizio Federico

Published in: International journal of nanomedicine (2019)

Our data represent the proof-of-concept for the possibility to target intracellular antigens through EV-mediated delivery of scFvs. This finding could be relevant to design novel methods of intracellular therapeutic interventions.

Keyphrases

reactive oxygen species
induced apoptosis
high grade
signaling pathway
cell cycle arrest
physical activity
electronic health record
dendritic cells
oxidative stress
immune response
cell death
cell proliferation
deep learning
pi k akt