Consideration of within-patient diversity highlights transmission pathways and antimicrobial resistance gene variability in vancomycin-resistant Enterococcus faecium.
Martin P McHughKerry A PettigrewSurabhi TaoriThomas J EvansAlistair LeanordStephen H GillespieKate E TempletonMatthew T G HoldenPublished in: The Journal of antimicrobial chemotherapy (2024)
Patients can carry multiple sequence types of VREfm, and even within related lineages the presence of mobile genetic elements and antimicrobial resistance genes can vary. VREfm within-patient diversity could be considered in future to aid accurate resolution of transmission networks.
Keyphrases
- antimicrobial resistance
- genome wide
- end stage renal disease
- case report
- ejection fraction
- newly diagnosed
- chronic kidney disease
- copy number
- prognostic factors
- peritoneal dialysis
- high resolution
- dna methylation
- methicillin resistant staphylococcus aureus
- single molecule
- mass spectrometry
- pseudomonas aeruginosa
- escherichia coli
- amino acid
- genome wide analysis
- patient reported