Phosphorylation of androgen receptor by mTORC1 promotes liver steatosis and tumorigenesis.

Qian-Nan RenHong ZhangChao-Yue SunYu-Feng ZhouXue-Feng YangJian-Wu LongXiao-Xing LiShi-Juan MaiMei-Yin ZhangHui-Zhong ZhangHai-Qiang MaiMin-Shan ChenX F Steven ZhengHui-Yun Wang

Published in: Hepatology (Baltimore, Md.) (2021)

AR S96 phosphorylation by mTORC1 drives liver steatosis and HCC development and progression independently and cooperatively with androgen, which not only explains why HCC is man-biased but also provides a target molecule for prevention and treatment of HCC and a potential survival predictor in patients with HCC.

Keyphrases

insulin resistance
high fat diet
protein kinase
adipose tissue
metabolic syndrome
replacement therapy
smoking cessation