Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells.

Nihal AlMuraikhiDalia AliRadhakrishnan VishnubalajiMuthurangan ManikandanMuhammad AtteyaAbdulaziz SiyalMusaad AlfayezAbdullah AldahmashMoustapha Kassem Nehad M Alajez

Published in: Stem cells international (2019)

We identified γ-secretase inhibitor (LY411575) as a potent regulator of osteoblastic differentiation of hBMSC that may be useful as a therapeutic option for treating conditions associated with ectopic bone formation.

Keyphrases

mesenchymal stem cells
endothelial cells
induced pluripotent stem cells
transcription factor
bone marrow
anti inflammatory