Drug concentration at the site of disease in children with pulmonary tuberculosis.
Elisa López-VarelaAhmed A AbulfathiNatasha StrydomPierre GoussardAbraham C van WykAnne Marie DemersAnneen Van DeventerAnthony J Garcia-PratsJohannes van der MerweMatthew ZimmermanClaire L CarterJacques JansonJulie MorrisonHelmuth ReuterEric H DecloedtJames A SeddonElin M SvenssonRob WarrenRadojka M SavicVéronique DartoisAnneke C HesselingPublished in: The Journal of antimicrobial chemotherapy (2022)
Despite similar penetration characteristics compared with adults, low plasma exposures in children led to low site of disease exposures for all drugs except for isoniazid.