Acute Cardiovascular Effects of Non-Invasive Electrical Spinal Cord Stimulation: Results from a Pilot Study in Humans.
Evgeny N M MikhaylovTatiana R MoshonkinaElena N ZharovaSvetlana V GarkinaPavel D KovzelevNatalia N BelyaevaAndrey V KozlenokDmitry S LebedevEvgeny V ShlyakhtoPublished in: Journal of cardiovascular translational research (2020)
We aimed to determine if non-invasive electrical spinal cord stimulation (NIE-SCS) is associated with acute changes in systemic and pulmonary hemodynamics and cardiac electrophysiology at rest. Nine subjects without structural heart disease referred for catheter ablation of cardiac arrhythmia were included. NIE-SCS was performed in each patient at vertebral levels T1, T7, and T11. Higher systolic BP (BPs) was detected during T1 NIE-SCS as compared with baseline (147.9 ± 22.5 vs 135.4 ± 17.4 mmHg; P = 0.02). Atrioventricular nodal effective refractory period (AVN ERP) was shorter during stimulation at T1 and T7, when compared with baseline values (baseline 303.3 ± 15.0 vs 272.0 ± 19.2 for T1 vs 278.0 ± 8.3 ms for T7; P < 0.05). NIE-SCS at the T1 level is associated with an elevation of BPs. NIE-SCS at the T1 and T7 levels shortens AVN ERP. Further studies are needed for the evaluation of chronic effects.
Keyphrases
- catheter ablation
- spinal cord
- liver failure
- atrial fibrillation
- left ventricular
- drug induced
- left atrial
- respiratory failure
- pulmonary hypertension
- spinal cord injury
- heart failure
- blood pressure
- neuropathic pain
- multiple sclerosis
- left atrial appendage
- aortic dissection
- mass spectrometry
- lymph node
- ms ms
- case report
- intensive care unit
- hepatitis b virus
- mechanical ventilation
- extracorporeal membrane oxygenation
- rectal cancer