PI3K Inhibitors Curtail MYC-Dependent Mutant p53 Gain-of-Function in Head and Neck Squamous Cell Carcinoma.

Federica GanciClaudio PulitoSara ValsoniAndrea SacconiChiara TurcoMahrou VahabiValentina MancioccoEmilia Maria Cristina MazzaJalna MeensChristina KaramboulasAnthony Charles NicholsRenato CovelloRaul PelliniGiuseppe SprianoGiuseppe SanguinetiPaola MutiSilvio BicciatoLaurie AillesSabrina StranoGiulia FontemaggiGiovanni Blandino

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2020)

Collectively, the blocking of this transcriptional network is an important determinant for the response to BYL719 in HNSCC.

Keyphrases

transcription factor
gene expression
wild type
heat shock protein