A DM1-doped porous gold nanoshell system for NIR accelerated redox-responsive release and triple modal imaging guided photothermal synergistic chemotherapy.
Pengcheng XuRu WangWenqian YangYanyan LiuDongsheng HeZixuan YeDaquan ChenYuan DingJiasheng TuYan ShenPublished in: Journal of nanobiotechnology (2021)
The prepared DM1-mPEG/HER-PGNSs enabled nanodart-like tumour targeting, visibility by CT, PA and PT imaging in vivo and powerful tumour inhibition mediated by chemo-thermal combination therapy in vivo. In summary, these unique gold nanocarriers appear to have good potential as theranostic nanoagents that can serve both as a probe for enhanced multimodal imaging and as a novel targeted anti-tumour drug delivery system to achieve precision nanomedicine for cancers.
Keyphrases
- cancer therapy
- combination therapy
- photodynamic therapy
- drug delivery
- high resolution
- fluorescence imaging
- quantum dots
- drug release
- magnetic resonance imaging
- adipose tissue
- squamous cell carcinoma
- magnetic resonance
- computed tomography
- locally advanced
- contrast enhanced
- weight loss
- silver nanoparticles
- mass spectrometry
- highly efficient
- metal organic framework
- pain management
- climate change
- image quality
- pet ct
- electron transfer
- fluorescent probe