Enhanced antitumor immunity through sequential targeting of PI3Kδ and LAG3.

Sarah Nicol LauderKathryn SmartVeerle KersemansDanny AllenJake ScottAna PiresStefan MilutinovicMichelle SomervilleSean SmartPaul KincheshElena Lopez-GuadamillasEllyn HughesEmma JonesMartin ScurrAndrew GodkinLori S FriedmanBart VanhaesebroeckAwen Gallimore

Published in: Journal for immunotherapy of cancer (2021)

These data indicate that LAG3 is a key bottleneck to successful PI3Kδ-targeted immunotherapy and provide a rationale for combining PI3Kδ/LAG3 blockade in future clinical studies.

Keyphrases

cancer therapy
clinical trial
data analysis
artificial intelligence