Contribution of aldehyde oxidase to methotrexate-induced hepatotoxicity: In Vitro and pharmacoepidemiological approaches.

Ayako MoriyamaHinata UedaKatsuya NarumiShuho AsanoAyako FurugenYoshitaka SaitoMasaki Kobayashi

Published in: Expert opinion on drug metabolism & toxicology (2024)

AOX inhibition contributed to MTX accumulation in the liver, resulting in increased hepatotoxicity. Our study raises concerns regarding MTX-related hepatotoxicity when co-administered with drugs that possibly inhibit AOX activity at clinical concentrations.

Keyphrases

drug induced
high glucose
high dose
diabetic rats
endothelial cells