Analysis of copy number variations of WNT4 gene in a Chinese population with Müllerian anomalies.
Ying ZhuRuyi WangYun ChengYang HanTengyan LiYunxia CaoBin-Bin WangPublished in: Orphanet journal of rare diseases (2021)
MLPA identified one heterozygous deletion in WNT4 in a single female patient among 248 Chinese women affected by MA. This study firstly reports CNVs of WNT4 in a large sample of MA patients from the Chinese population, which suggests that CNVs of WNT4 cannot be excluded in the occurrence of MA. This provides a genetic basis for precise treatment in the future.
Keyphrases
- copy number
- cell proliferation
- mitochondrial dna
- stem cells
- genome wide
- end stage renal disease
- ejection fraction
- newly diagnosed
- dna methylation
- risk assessment
- polycystic ovary syndrome
- prognostic factors
- peritoneal dialysis
- type diabetes
- case report
- emergency department
- transcription factor
- patient reported outcomes
- combination therapy
- patient reported