Arglabin could target inflammasome-induced ARDS and cytokine storm associated with COVID-19.
Azadeh ManayiSeyed Mohammad NabaviMaryam KhayatkashaniSolomon HabtemariamHamid Reza Khayat KashaniPublished in: Molecular biology reports (2021)
Arglabin (l(R),10(S)-epoxy-5(S),5(S),7(S)-guaia-3(4),ll(13)-dien-6,12-olide), is a natural sesquiterpene γ-lactone which was first isolated from Artemisia glabella. The compound has been shown to possess anti-inflammatory activity through inhibition of the NLR Family pyrin domain-containing 3 (NLRP3) inflammasome and production of proinflammatory cytokines including interleukin (IL)-1β and IL-18. A more hydrophilic derivative of the compound also exhibited antitumor activity in the breast, colon, ovarian, and lung cancer. Some other synthetic derivatives of the compound have also been synthesized with antitumor, cytotoxic, antibacterial, and antifungal activities. Since both NLRP3 inflammasome and cytokine storm are associated with the pathogenesis of COVID-19 and its lethality, compounds like arglabin might have therapeutic potential to attenuate the inflammasome-induced acute respiratory distress syndrome and/or the cytokine storm associated with COVID-19.
Keyphrases
- nlrp inflammasome
- acute respiratory distress syndrome
- coronavirus disease
- sars cov
- extracorporeal membrane oxygenation
- mechanical ventilation
- high glucose
- diabetic rats
- respiratory syndrome coronavirus
- intensive care unit
- oxidative stress
- endothelial cells
- liquid chromatography
- anti inflammatory
- candida albicans
- high resolution
- stress induced
- solid phase extraction