Quantitative determination of lurbinectedin, its unbound fraction and its metabolites in human plasma utilizing ultra-performance LC-MS/MS.

Nicholas KingSoledad Garcia-MartinezEider AlcarazAlba GrisalenaRubin LubomirovRaquel AltaresCarlos Fernandez-TeruelAndrés M FranceschPablo M AvilésSalvador Fudio

Published in: PloS one (2023)

These UPLC-MS/MS methods enable the rapid and sensitive quantification of lurbinectedin and its main metabolites in clinical samples.

Keyphrases

ms ms
high resolution
liquid chromatography tandem mass spectrometry
simultaneous determination
molecularly imprinted
solid phase extraction
high performance liquid chromatography
loop mediated isothermal amplification
liquid chromatography
sensitive detection