UDP-Glucose/P2Y14 Receptor Signaling Exacerbates Neuronal Apoptosis After Subarachnoid Hemorrhage in Rats.
Hideki KanamaruShiyi ZhuSiyuan DongYushin TakemotoLei HuangPrativa SherchanHidenori SuzukiJi-Ping TangJohn H ZhangPublished in: Stroke (2024)
These findings suggest a detrimental role of brain UDP-G/P2Y14 signaling in SAH, as a part of glucose metabolic pathology at the tissue level. P2Y14 inhibitor 4-[4-(4-piperidinyl)phenyl]-7-[4-(trifluoromethyl)phenyl]-2-naphthalenecarboxylic acid hydrochloride may serve as a potential therapeutic target in treating patients with SAH.
Keyphrases
- subarachnoid hemorrhage
- cerebral ischemia
- brain injury
- blood glucose
- oxidative stress
- blood brain barrier
- endoplasmic reticulum stress
- cell cycle arrest
- resting state
- human health
- multiple sclerosis
- functional connectivity
- risk assessment
- type diabetes
- signaling pathway
- climate change
- metabolic syndrome
- weight loss
- pi k akt