Novel confocal Raman microscopy method to investigate hydration mechanisms in human skin.
Hequn WangQihong ZhangGuangru MaoOscar ConroyYelena PyatskiMichael J FevolaGabriela Oana CulaPrithwiraj MaitraRichard MendelsohnCarol R FlachPublished in: Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) (2019)
Unique information regarding hydration mechanisms are obtained from CRM experiments using D2 O as a probe. The source and relative rates of hydration can be delineated using ex vivo skin with D2 O underneath. One can envision comparing these depth-dependent rates in the presence and absence of topically applied hydrating agents to obtain mechanistic information.