Macro-clusters: CD301b+ DCs prime Th2 responses.

Published in: The Journal of experimental medicine (2024)

In this issue of JEM, Lyons-Cohen et al. (https://doi.org/10.1084/jem.20231282) reveal that lymph node macro-clusters provide a spatial niche where CD301b+ cDC2s and CD4+ T cells interact. These integrin-mediated cellular hubs promote enhanced co-stimulation and cytokine signaling to drive Th2 differentiation.

Keyphrases

lymph node
nk cells
neoadjuvant chemotherapy
cell cycle
sentinel lymph node
radiation therapy
cell proliferation
cell migration
rectal cancer
locally advanced