Modulation of mitochondrial DNA copy number in a model of glioblastoma induces changes to DNA methylation and gene expression of the nuclear genome in tumours.

Published in: Epigenetics & chromatin (2018)

Our results highlight the bidirectional control of the nuclear and mitochondrial genomes through modulation of DNA methylation to control mtDNA copy number, which, in turn, modulates nuclear gene expression during tumorigenesis.

Keyphrases

copy number
dna methylation
mitochondrial dna
gene expression
genome wide
oxidative stress
sensitive detection
living cells
fluorescent probe
quantum dots