Mechanisms of pulmonary disease in F344 rats after workplace-relevant inhalation exposure to cross-linked water-soluble acrylic acid polymers.
Shotaro YamanoTomoki TakedaYuko GotoShigeyuki HiraiYusuke FurukawaYoshinori KikuchiKyohei MisumiMasaaki SuzukiKenji TakanobuHideki SenohMisae SaitoHitomi KondoYoichiro KobashiKenzo OkamotoTakumi KishimotoYumi UmedaPublished in: Respiratory research (2023)
The present study reports our findings on the cellular and molecular mechanisms of pulmonary disease in rats after workplace-relevant inhalation exposure to CWAAP-A. This study also demonstrates that the lung pathogenesis of rats exposed to CWAAP-A by systemic inhalation was qualitatively similar to that of rats administered CWAAP-A by intratracheal instillation.