TERT promoter mutations in penile squamous cell carcinoma: high frequency in non-HPV-related type and association with favorable clinicopathologic features.
Sang Kyum KimJang-Hee KimJae Ho HanNam Hoon ChoSe Joong KimSun Il KimSeol Ho ChooJi Su KimBumhee ParkJi Eun KwonPublished in: Journal of cancer research and clinical oncology (2021)
Our study shows TERT-p mutations are the most frequent somatic mutations in penile SCC. In addition, TERT-p mutations are far more frequent in non-HPV-related penile SCC than in HPV-related penile SCC, indicating TERT-p mutations may have a role in tumorigenesis distinct from HPV-related penile SCC.