Dynamic Molecular Markers of Otosclerosis in the Human Cochlea.

Sarah E Hodge Ivan A LopezAlex CronkiteJohn HouseHirooki MatsuiGail IshiyamaAkira Ishiyama

Published in: The Annals of otology, rhinology, and laryngology (2024)

Our results propose that the activity and function of TGF-1 may play a key role in the development and pathogenesis of otosclerosis. Further studies utilizing a higher number of temporal bone specimens will be helpful for future analysis and to help decipher its role as a potential target in therapeutic interventions.

Keyphrases

endothelial cells
bone mineral density
current status
induced pluripotent stem cells
soft tissue
epithelial mesenchymal transition
climate change
signaling pathway