Epigenetic Alternations of MicroRNAs and DNA Methylation Contribute to Liver Metastasis of Colorectal Cancer.

Jingwei LiuHao LiLiping SunShixuan ShenQuan ZhouYuan YuanChengzhong Xing

Published in: Digestive diseases and sciences (2019)

Our study identified a series of differentially expressed genes which are associated with epigenetic alternations of miRNAs and DNA methylation in colorectal liver metastasis. Up-regulated genes of SLC10A1, MAPT, SHANK2, PTH1R, and C2, as well as down-regulated genes of CAB39, CFLAR, CTSC, THBS1, and TRAPPC3 were associated with both miRNA and DNA methylation, which might become promising biomarker of colorectal liver metastasis in future.

Keyphrases

dna methylation
genome wide
gene expression
copy number
bioinformatics analysis
genome wide identification
transcription factor